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1.
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SOM230:
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Some of you reading this may already be enrolled in this study. Currrently, no more study participants are needed. SOM 230 is a relative/analog of somatostatin. See item 7.-5. below for more information.
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2.
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SU011248:
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This substance is a multiple receptor tyrosine kinase inhibitor that has anti-angiogenic activity. A multisite study of it in patients with neuroendocrine tumors was started in spring 2003. No information on this study was available at www.clinicaltrials.gov in mid-February 2004, so we cannot tell you if this trial is still recruiting.
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3.
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Octreoscan a Phase 4 study:
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This information was received in mid-December 2004 by e-mail from a clinical trials representative from TycoHealthcare, which recently bought Mallinckrodt,the company that produces the materials to do octreoscans (another name for the procedure is somatostatin receptor scintigraphy). The following information ithat was provided by the company is presented here because it is not available at www.clinicaltrials.gov
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4.
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PTK-787:
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Dr. Lowell Anthony is expected to start a clinical trial of this test drug soon. (noted in mid-February 2005). Here is a definition found in the National Cancer Institute’s dictionary of terms: PTK787/ZK 222584 --- A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called protein tyrosine kinase inhibitors and VEGF receptor kinase inhibitors. Also called vatalanib
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5.
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Radionuclides
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The concept here is to use somatostatin analogs with radioactive materials attached that have a chance to destroy neuroendocrine tumor tissue when the octreotide or octreotate carrying the radioactive material attaches to a somatostatin receptor on the tumor.
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6.
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Radiofrequency ablation/RFA
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7.
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Clinicaltrials.gov website
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The trials on this page were identified in a search of the www.clinicaltrials.gov website. When you search, you can choose only active trials that are still recruiting or you can ask for all trials and find some that are no longer recruiting and others that are completed. The list below shows selected samples (as of mid-February 2005); it is not all inclusive.
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This page was last updated March 1, 2005.
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